On Purpose with Jay Shetty

Bryan Johnson: New SHOCKING Science on How to Reverse Your Age by 31 Years & The Damaging Impact of 1 Bad Night Sleep


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Do you think one bad night of sleep can really harm your body?

Would you try a routine that could help you reverse aging?

Today, Jay sits down with Bryan Johnson, entrepreneur and founder of Blueprint, who is redefining human health and longevity. Dubbed “the world’s most measured human,” Bryan shares his extraordinary journey of reversing aging and improving biological performance through science-backed methods and a meticulously designed lifestyle.

Bryan discusses how his $2 million-a-year protocol isn’t just about extreme spending but about pioneering a blueprint for everyone. He explains the concept of “don’t die,” emphasizing the potential for humanity to extend life and improve health at unprecedented levels. From his diet of precision-crafted meals to his groundbreaking work in measuring microplastics and organ health, Bryan’s insights challenge conventional norms about aging, health, and longevity.

Together with Jay, Bryan dives deep into actionable takeaways, such as the five pillars of perfect sleep, the importance of building systems over relying on willpower, and how to minimize exposure to environmental toxins like microplastics. Bryan also addresses controversial topics, including the downsides of cheat days and the role of technology in managing health.

In this interview, you’ll learn:

How to Reverse Aging Through Measured Health Metrics

How to Optimize Your Diet for Longevity

How to Manage Stress With Better Sleep

How to Create a System for Healthy Living

How to Rewire Your Taste Buds for Better Nutrition

How to Lower Inflammation With Simple Daily Habits

You don’t need millions of dollars or cutting-edge technology to start—just a commitment to making small, intentional changes. 

With Love and Gratitude,

Jay Shetty

Check out the On Purpose Merch! https://jayshettyshop.com. 100% of Proceeds are donated to National Alliance on Mental Illness. NAMI is the nation’s largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness.

What We Discuss:

00:00 Intro

02:31 How Long Can a Person Live?

04:19 The Most Measured Person

06:34 Getting Sustained Hearing Impairment

09:57 Extending Life Before Conception

11:18 How Long Do We Have to Live?

14:22 Every Body I Highly Responsive to Change

16:50 Embryo Selection Through Genetic Markers

18:12 A Generation of Microplastic 

20:42 Simple Ways to Minimize the Influx of Microplastic

23:05 Don’t Drink from Water Bottles

26:01 The Significant Health Threat of Air Pollution

30:11 How Capitalism Affects Health

32:28 5 Ways to Get Better Sleep

40:12 Don’t Miss Your Deep Sleep Window

43:37 The Ill Effects of Poor Sleep

45:48 Invest in Your Health

48:12 What’s Your Protein Intake?

51:22 Bryan’s Perfect Diet

56:11 Eating 3 Meals a Day in 5 Hours

58:21 Rewire Your Taste Buds

59:19 Sensitivity to Air Quality

01:02:36 Are You Scared of Dying?

01:05:58 Prolonging Longevity

01:08:07 Ways to Manage Stress

01:11:00 You Are not Your Thoughts

01:15:37 Health Can Lead to Happiness

01:19:37 Is Reverse Aging Possible?

01:22:25 Bryan on Final Five   

Episode Resources:

Bryan Johnson | Website

Bryan Johnson | X

Bryan Johnson | Instagram 

Bryan Johnson | Tiktok 

Bryan Johnson | Youtube

Bryan Johnson | LinkedIn

Blueprint Protocol

See omnystudio.com/listener for privacy information.

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